I use glue all the time in my piecing process. I too try to keep the glue to a minimum and outside the stitching line as to not gum up my machine needle. When I go to quilt it I have not found any issues when I hit the glue areas........so far but then I use robotics in my quilting so I wouldn't know if and when I hit an area anyway. So far I don't see any problems with the quilt stitches. I also use the glue while applying the binding on before I take it to the machine to stitch down. Saves having to use pins and pricking myself leaving blood on the quilt. I then wash the quilt to remove any glue, markings, etc. before I give it to the recipent.