I think it could work, but will take a bit more preparation than normal. I believe you will need to use a spray baste to keep every inch stuck to the batting while you quilt.....and be ready to do more quilting than normal as any areas bigger than your fist will sag/stretch without quilting. I have knit sheets on my bed and they do stretch, but add some extra warmth in the winter. It is your quilt, so don't let someone else tell you that your quilt will be ruined with a knit backing!