I still piece 95% of my quilts by hand. I have been known to "whip" one out on the machine, but the machine is not portable, whereas hand-piecing is. I usually will work on my quilts at appointments, while riding in the car, or when I am watching tv. It takes me a lot longer to do it by hand, but I am usually not in a hurry to get it done, anyway, and I don't feel any pressure about that 1/4 inch seam. I am pretty good about 'eyeballing' my seams, and my seams all match up. I am in awe of those who can complete a quilt in a month or less; it usually takes me 2-3 months by hand. It depends on the pattern if it is hand-quilted or machine quilted. I have found that I like the piecing, not so much the quilting; seeing it all come together is great, but once it is done, so am I. I have a wonderful LA-er, as well as my local senior group to do the quilting for me. Win-Win for me. I get a beautiful quilt that I didn't have to quilt.
Whatever you choose, do it for your own enjoyment.