I used homespun with old blue jeans for my father in law as a comforter for his bed in the nursing home. He used it constantly and the denim blocks gave out first and it lasted about 5 years with heavy use. The homespun blocks never frayed out on that comforter. When the first one wore out I made another just like the first. I'd do the same thing again with no worries. I didn't treat the seams any different than anything else I've made.
JB