There are significant differences in different threads. What I think is best are very long staple threads since they have fewer "fuzzies." You can see the difference if you unroll some thread and look at it carefully. I really like Superior threads in general, but I also use Gutterman and Aurifil a lot. My all time favorite piecing thread is So-Fine by Superior. It sews like cotton, but it has almost no fuzz since it is really a polyester thread. For quilting, I use all kinds, depending on the look I am going for.