Winter - 64 during the day, and 54 at night. We also have a programmable thermostat that kicks on about 30 minutes before we get up, so we don't get up to a 54 degree house. We also spend our evenings in the family room, with a gas fireplace, and will use that in the winter. We stay comfortable.
Summer - about 76-78, depending on how active we are. We have a whole house fan, so don't turn on the AC until the outside temp or dew point doesn't drop below 70 at night.