Instead of pulling each layer taut when layering, I lay them on top of the first one, pat and pull gently while using Sullivan's spray. The "patting" really works especially for the batting. For each layer, I spray a section at a time and work my way down the quilt. So far I've never had a wrinkle.
BTW, this also works for binding - I do not measure and cut the binding or borders and then try to make them fit. I cut it a few inches longer (4-6") and just layer it onto the quilt pinning just 6" to 12" ahead of the needle. Then I'll trim the corners. Again, no wrinkles ever.