I've been looking into it for my first hand quilted baby quilt and tried out a small sample, but ultimately decided on the Hobb's Organic Cotton. Indycat32 is right that there are multiple thicknesses of QD. The thinnest one (request) is often recommended for hand quilting, but it really gives almost no definition at all to your quilting which just really seems a shame to me to put all that work into something & not to be able to see the quilting really well. The 2nd thinnest (select) is what I would use if I were using QD because it provides some definition, but is still thin enough for hand quilting. The select & supreme weights are really too thick to hand quilt unless maybe if you are doing the big stitch quilting.
The nice thing about QD batts is that they don't have a scrim like W&N does. That means you have to quilt no farther apart than every 8" instead of the 10" for W&N, but I've never been successful with quilts holding up with such sparse quilting regardless of the instructions on the batting package so that hasn't made a difference to me.