I am barefoot in my home (and therefore sewing room) pretty much 100% of the time. All toes still intact, and I never step on pins because if I drop one I don't leave the room until I find it! I have 3 dogs and 2 cats and would hate to have one of them find and possibly eat a pin, so I just don't leave any. I have a stick with a powerful magnet at the end that makes it really easy to find any dropped pins.
I have tried sewing standing up and it didn't go well for me. I don't like using the start/stop button on my machine, I REALLY prefer the pedal and I couldn't find a good way to stand and also use the pedal comfortably. The best I found was to control it with my heel and keep my toes on the ground, but that eventually gave me cramps in my calf. If you have the start/stop button on your machine and are used to using it, I think sewing standing up would be a lot easier, but for me it didn't work out.