I spray baste and get pretty good results this way - after making sure my backing and batting are bigger than my top, I find and pin mark the approximate center of each layer.
Starting with the batting and backing, I fold each into quarters and match up the centers I marked earlier.
Spray the batting, smooth the backing, open one fold on each so now I am able to spray the rest of that half.
Spray and smooth again, flip open the unbasted half, spray about 1/2 of the batting again.
So working in quarters more or less, it makes a large quilt manageable for me.