I have quilted many times in a RV, the only downside for me was like sewing before I had a sewing room. I was constantly having to put my sewing up because it was all over the place. We live 5 months in a Park Model in TX. I have a little more room. I also cut out projects to bring with me and it is much easier that way. But go for it, where there is a will there is a way.