Yes, I've done flannel/ denim combos....even put batting in between and sewed a large x to keep it together......then when I sewed those blocks together, I alternated one flannel, one denim...so front and back are checkerboard, only one side ragged, though....took to laundromat and washed twice to get good rag look....come to think of it, I did not prewash that flannel, and the denim was from garage sale jeans.......and it is fine......weighs a ton, but dd loves it!