I always use 100% cotton thread in neutral colors on my quilts because I am using 100% cotton fabric. I can pretty much make a large quilt using a regular large spool of mettle cotton thread. I stay away from Coats & Clark thread because I found it was not as strong and linty. Also I can't afford expensive thread like Aurifil. But for heavens sake the price of fabric nowadays maybe my quilting days are limited anyway!