It made me feel really good to clean out many items that no longer made me happy. I can't think of a single thing I wish I had kept. Start with some of the things you really don't want and see if you don't feel "lighter". Stuff can weigh you down.
When we cleaned out my mother-in-law's closet I counted over 100 pairs of black pants. You will be doing your relatives a great service by cleaning out now. Think of it as a gift to them.