Yes I've done that. I used a yard of cotton and a yard of flannel and birthed it without batting. I quilted it by starting at one edge and sewing 1 1/2" from the edge all the way across until 1 1/2" from the next edge, pivoting to sew the next line, etc. until I got to the middle. Very easy, very quick and it's been one of my DDs favorite blankets to use for her kids.
Cari