Two of the first quilts I ever made, more than 20 years ago, were hand-pieced hexagons. Both on the small side but I loved doing them. I've got several more either cut out waiting or in the planning stages. As far as I'm concerned hand piecing hexagons is just as easy as piecing squares. The only thing I could probably never do again is quilt the top 1/4" away from the seams on small (like 1 inch) hexagon tops. It made the seams more prominent, but it was only the second top I hand quilted, so I had a lot to learn.