I do all robotic quilting so it will depend on how the quilt is laid out (the type of blocks). One quilt was all wide strips laid up and down and I wanted to do a feather chain down the length of it so my best bet was attaching it lengthwise across the frame instead of widthwise. I chunk my borders so it doesn't matter which direction the quilt is for that portion.
Otherwise I would think it would depend on how you want the quilting to look on that particular quilt. Sometimes if the pantos is close enough you can't tell where one row stops and the next one starts. Looks like all one big pattern.