Absolutely for garments or home dec sewing.
I would only put it in a quilt if it was going on the wall (i.e., an Art Quilt). And even then, only if it were meant to be a fun piece. Synthetic fibers behave very differently from cotton fibers. I like my quilts to last a very, very long time. Over the decades, poly fibers will hold their color & most of their strength while cotton fibers fade & break down, so in a blend, the poly fibers actually cause the cotton fibers to snap more quickly than they would on their own. Blends don't always work well with fusible & will launder/iron differently than 100% cotton. In a garment that is maybe going to last 5-10 years at the most, none of that's an issue. With a quilt that I hope lasts 50+ years, all those little things make a difference to me.