I just finished a 48 X 48 and did not start in the center. I started at one corner and worked on the diagonal from corner to corner. Then I quilted to the right of that diagonal then to the left, making a grid pattern on the diagonal. I then had areas that needed to have meanderings. Where you start may depend on the size of the quilt and the pattern.
Prism 99, I hate all the little ends that end up having to be tied off and buried too. So this time after each trip of meandering, again on the diagonal, I started with a filled bobbin and yippee I do not have any ends to tie off. It got pretty close a couple of times but I learned to slow down and watch the bobbin! I did not take any chances with "maybe" the bobbin thread will make it to the end. Just changed to a new bobbin and I am just sooooo happy!

