I've only used 100% when hand quilting. Unlike many others here, I use Warm & Natural - which does have a scrim - but do not find it overly difficult to quilt. Then again, if I ever used something else, I'd probably feel differently. I, too, prefer all natural quilts as they do breathe better. I find them warmer in winter and cooler in summer. I also like the 'crinkle' look that 100% cotton battings give after washing.