Our local children's hospital has a sewing room. I volunteer there once a week, for about 5 hours. We sew items used on the hospital units - shorts for physical therapy, elbow restraints, tube covers, bibs, etc. I never know what I will be working on.
The local Salvation Army has a toy auxiliary. As part of that I sew clothes for 18" dolls. They give away close to 700 18" dolls each year.
I have also volunteered at Matthew 25 ministries. I like this one because you just show up and they give you a task. It's a great way to catch up with friends while doing something useful. The oddest task I have had there was sorting miscut feminine hygiene products, trying to selvage any that could still be used.