I suppose if you are making more than one quilt you can put the fun, novelty prints in one quilt and the sophisticated prints in another. Sometimes scrappy quilts are not totally random. I like to use a unifying color as a sashing or a consistent light color for a background of scrappy stars, for example.
Or add other elements besides the 2.5" squares. One example is combining a 16-patch block of 2.5" squares with a pinwheel block. Another example is combining a 25- patch block of 2.5" squares with either a snowball block or an eight pointed star. It gives the eye a place to rest, and can form a chain effect.