I once made a large hand appliqued wall hanging and put their name and date of their wedding. I think it turned out to be about 24 x 36". They loved it. I really wish I would have remembered to take a photo of it, but I forgot. Oh well.
The block that I used was from a book, "The Country Lily Quilt" by Benner & Pellman.
Although hand appliqueing it took a long time, it didn't take as long as making a big quilt for them and it was received with just as much excitement. Even machine applique would be just as nice with their names and date of their wedding made into a pillow would be really a sweet gift.