I have done it several times for childrens quilts on my LA.
Is the wedding quilt going to be bed size - full, queen, or king? (Maybe 'cuddle quilt" means throw size?) I know that JoAnns had some 90 inch wide fleece a year of so ago, so you might be able to do a queen size with one long piece of fleece. Otherwise, you have to sew it together.
On the childrens quilts, I put the fleece on the frame WOF across, length of fabric for the length of the quilt. There is less give on the WOF than on the length of the fabric, so it quilts up with fewer problems, less stretching, etc. I also apply light side tension using side "leaders" to keep the fabric from sagging or stretching while quilting.
Some of the fleece backed quilts had batting, some did not. Overall, I liked the ones with batting better and thought they quilted up better.
I did quilt one fleece backed quilt on my DSM and it turned out well. I think I got lucky!