I have done pantos for many yrs. I line up the first row with top of quilt on leader, start one side with beginning of panto and usually have to fake the end ( I put under the clear plastic that is attached to my table) I use an wer dry marker to redo the end. If it's a straight top/ bottom of design i use two finger space between rows, if it's a wavy, there's usually a guide from previous row to guide you...and bottom row rarely ends up even with a panto, so there too I redraw to matech edge of quilting area....just my way