Prism99

This will be harder to hand quilt because of the scrim, but not impossible. There are other battings that are easier to hand quilt. You *really* need to make a small practice sandwich to hand quilt, as this will teach you a lot about ease/difficulty, thread tangles, needle and thimble, etc.

Also, I just want to mention that machine quilting is also perfectly acceptable on a quilt like this. You may not want to rule it out so early.

Edit: If you really want to hand quilt this as an heirloom, I would recommend switching to Hobbs wool batting. It is much easier to quilt and is considered an heirloom quality batting. Its only downside is that it is a little more expensive than cotton. The first quilt I ever hand quilted was 100% cotton (Mountain Mist blue ribbon batting), and I remember the difficulty I had with it. Cotton creates much more drag on the needle than wool, and scrim increases that drag. To be honest, at my age, I would hand quilt only with wool or silk batting now.