I think just about any traditional pattern can be done with homespuns. Log cabins, Sawtooth star, Maple leaf, square in a square, churn dash, 9 patch, the list is endless. One of our members did a fabulous pineapple quilt using mens shirts.
http://www.quiltingboard.com/picture...e-t254529.html
I did a cat quilt using homespuns:
(3rd pic in post)
http://www.quiltingboard.com/picture...ts-t22342.html
If you google images of "homespun quilts" you will get loads of ideas and also go to Bonnie Hunter's website for even more ideas.
http://quiltville.blogspot.com/
I think the key is, whatever pattern you pick make sure you have a good strong contrast in value. Ynglady's and Chester the bunny have posted excellent examples of how striking they can be mixed with a light solid as well.