I'm a hand quilter - and yes, this can be placed into a frame and quilted a little at a time. Joanne's provided me with a nice quilting frame, made of pvc pipe? I baste my quilts with a brighter color than I quilt with, and once it's all stretched and basted with large stitches, I quilt. Once it's all done, I pull out the brighter basted stitches - wallah! If using a lap quilting frame, the same process can be done.