I did my last one on the floor but my hamstrings reminded me of it for about a week! Personally, I think there is no good way and if I could avoid this quilting chore, I would. One of my sons wants a king size quilt, which I could possibly piece, but sandwich? I don't even want to think about it! Never mind trying to quilt it on a DSM.
That said, others here have good advice for what has worked for them.