No, never. I have 2 walls of wall shelves from about 5' high to the ceiling and some large tables. To me, it's too much trouble to move everything. I did a small rearranging when I got the Rocketeer and moved a table back in the sewing room that I had moved out. But I don't ever take everything out and start over. If I did that it would take me several weeks of weekend time to do and that would mean I wouldn't get to sew so it's just not worth what little I'd probably gain.
The next big re-arrange will be when (and if) I move.