Thank You all for the advice. I did get the permanent marker out and there are no signs of it happening. First I used Grandma's Spot Remover and had no luck. I let it air dry. That's when I put out my cry of help on here. So then I grabbed my cheap can of hairspray (Pantene brand). It did not say on the can if it was scented or unscented. I drenched it and let it soak 10 minutes and I held a cotton pad on the top of and underneath the fabric and tried to blot it. Unsuccessful again! Now I was really panicking because I have used hairspray in the past to get ink out of clothes and it worked like magic (but I think it was Rave brand. So I grabbed the Dawn dish soap and put it on the marked spot and let it soak a few minutes and scrubbed it a little with a toothbrush. Then I held a washcloth underneath it and sprayed with water and it came right out. Miracle! Thank God-- because this is really a customer's quilt, not mine! Thanks for all the advice you all gave to try to help me.