You can design a Mondrian quilt and it would be a custom design. EQ7 has a learning curve that requires patience and some dedicated time to work design functions. EQ offers classes and there are many online tutorials. I have never made the quilt you describe but I think it would be simple enough, if not time consuming because of the irregularity of the design.
I searched Pinterest for images of Mondrian quilts and some are quite irregular and some appeared to be broken into large regular segments, but color placement made it look more random and irregular. What stunning quilts they make and with the right quilting designs could be a fabulous work.