I have done a couple of quilts using variety of sized blocks, usually joined by strips of 2" pieces. You can do this by selecting 'Custom' type, or even with the 'photo patch'. You can draw up and save 'motifs' - for applique - and probably use these as blocks ( not sure if you would have to create a jpg image of them for the photopatch quilt as I haven't tried) but all the blocks can be resized to suit.
This is the last one I did last year, with my DIL who does not sew. She did well.
Is this what you are asking about?
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My old camera is stuck on the date and I can't figure out how to fix it.