I'm a prewasher. For shrinkage and bleeding. I used to think red was the only major culprit, but I had a turquoise batik that bled and bled and bled.
I have been doing quilting for donation quilts for veterans ... so lots of red/white/blue. The piecers usually don't prewash. quite often, when I spritz with water to remove my blue water-soluble markers, I see bleeding from the red.