I trim the excess off the quilt sandwich and sew the edges together - usually with a longish stitch about 3/16 inch from the edge.
I also baste the raw edges of bias cut binding together before sewing it to the quilt.
That way, i only have to line up "two" edges while sewing instead of five.
I also make wider bindings - approximately 7/16 inch finished width - because that is what works well using the leftmost needle setting on my favorite mschine.