I am assuming this is a sit down machine. If so, I think I would start in the middle and work my way out towards the edges. Kind of like a spiral. As long as the quilt is well basted (either with safety pins, glue, or spray baste) you shouldn't have issues. If you are planning on doing an all over meander I would not fill by block as I think it may appear obvious once the quilt is all done.
The few quilts I did on my domestic I never did an all over but I always started in the middle and worked my way out. Now I quilt on a longarm and my longarm is on a frame so I start at the top and work my way down and don't have to baste the sandwich.