I "bury the knot" just like in small stitch quilting. Believe it or not, those fat knots will pop into the fabric though it might take a little extra care. When I do straight line quilting across a piece, I just make sure it is long enough to go from end to end and the tails get sewn into the binding. If the piece is big, I start in the middle and only stitch with half the thread, then turn it and stitch the other half. Saves tangling and wear and tear on the thread.