It really does come down to how it will be quilted. If it is being longarmed (especially with a panto), the flange will be a huge headache. If you're quilting it on a domestic machine it will be less of a problem, because you will be able to easily keep track of it. It can still get flipped around if you FMQ over it, though, so when you plan your quilting try not to cross it.
If it's going to be longarmed, I would suggest a very narrow border instead.