I am quilting a 50 x 60 quilt using Hobbs poly down batting. I spray basted the quilt sandwich. I stitched in the ditch first making a plus sign to divide the quilt into 4 sections. I continued SITD quilting around the blocks to stabilize the quilt top. Next i did free-motion quilting using the plus sign through the quilt center to quilt each of the 4 sections.
This way you keep the bulk of the quilt always to the left. I also used a home sewing machine with a small throat space.