I am hand quilting a large queen sized quilt right now. I have only hand quilted a few baby quilts before this, and I did them hoopless. Unsure of how well the layers would hold on a 100" wide quilt, I decided to retrain myself to use a hoop and the Aunt Becky for the under hoop finger. I didn't last long with the hoop-- I'm back to hoopless. It feels much more natural to me without the heavy hoop and bulk of the large quilt. I spread the quilt over a bed and sit in an office chair next to it quilt.
I will say that I had basted with the double herringbone recommended by Sharon Schamber. Good basting is the big difference for me with hoopless hand quilting vs. machine quilting a large quilt. I'm wishing now that I had used closer spacing on my basting stitches because the top has lots of bias cut pieces and I'm quilting in large circles. Supplementing with safety pins is holding the sandwich together.
There are several videos on YouTube about hand quilting. All I can say is to watch a few, then practice to find out how to make your best stitches.