Do you already have a domestic machine with a large harp of at least 10"? If not, I highly recommend one (I use a Janome 8200) and it can handle a lot of fabric; it does wonderful FMQ, has lots of decorative stitches, does garment sewing because it has an arm, and doesn't take up much space.
I might eventually want a midarm, but so far this one suits the type of quilting (and sizes) I like to do. You really have to know yourself and your interests before you consider a big purchase.