I love the look of crinkly, well-loved quilts, so I rarely pre-wash my fabrics, and I always wash my quilts in hot water once they are completed. Only once have I ever had a problem, and it was before I discovered color-catchers, and because the fabric I used.
It was a quilt made from homespun fabrics of less than stellar quality. The main fabric was burgundy, and it bled horribly. After washing, the burgundy had faded terribly, and creams were tinged in pink. But, fifteen years later, that quilt is on my bed right now, and is one of my favorites.
Personally, I would just use the color catchers, making sure to check for bleeding before putting it into the dryer. If there is some bleeding, wash it again with more color catchers.
Also, if you are really concerned, you can wash the quilt with Synthropol to remove the extra dye after quilting. If you are prewashing your fabrics before making the quilt you could use Synthropol, then Retayne to set the dye. I don't think Retayne is recommended after piecing.