I spray baste the quilt sandwich first and then pin the four corners and a few along all four sides to insure the edges are taunt and won't come loose during the quilting process.
I begin with stitching a plus sign down the center of the quilt if there are rows that allow me to stitch in the ditch. Now the quilt is divided into 4 sections. I will continue to sitd from the inside out using the plus sign is my guide until my rows of blocks are done. If there are borders, I sitd those last. I can quilt all over designs or individual blocks and not worry about shifting. I read this method on a blog years ago.