I have not seen it done, but have seen the carding combs that were used, much the same way wool was prepared by brushing back and forth. I have a utility quilt made for me in 1957-58 and the cotton batting was bought at the dime store. It looks like the batting or wadding used in upholstery padding. There was no pattern for the top, just big pieces of feed sacks, same used for the backing. I've also seen photos of beautiful white and off-white quilts made by slaves in Virginia.
Barbara Brackman has written a lot on quilt history. Perhaps you can find more information on her website.