Do it before you are too old to drive. I would love to have a fifth wheel and travel, but still have my home to come home too at times, but at 83 and 86 my husband I are too old plus he has macular degeneration in one eye and does not see well enough to drive after dark and I know I am not capable of pulling a fifth wheel or parking it etc.
You will find a way to do some sewing, and quilting may not be like when you are at home but you will learn to do what you need to to have projects you can work on while on the road.
Happy quilting and hopefully happy rv'ing as well.