I have quilted several quilts on my small Brother machine. It can be harded with larger sized quilts. Lap quilts are the largest I don't mind quilting through the small neck space but there are quilters here who have done queen size quilts in their small DSM. First of all, how big is your quilt?
I find it easiest to quilt over all designs on larger quilts. Both of these are about 60"x80" and were quilted with a walking foot.