I have tried everything but the wool. I have used the new bamboo. A lot of it depends on the look you want. Dream Cotton request is the thing I use most often now. For my personal quilts I use the thinnest cotton or bamboo I can get. I am not crazy about Hobbs. I think it smells. IF a quilt has lots of applique or piecing I want to really stand out I will use poly. It is much lighter and makes the quilting more noticable. I will admit I purchase most of my batting on sale or with coupons. I have a decent stash.