A lot depends on your batting and how close the ties are. Warm and Natural is a very stable batting, so ties can be farther apart; however, it is hard to hand needle. It would be good for machine tying. For hand tying, I would consider Hobbs Polydown. The ties for that would need to be closer together, but the process of hand tying would be much easier.
Once you decide on a batting, be sure to make the ties close enough. Staggering the ties is a good idea, meaning if the first tow of ties is 4" apart, the next row should be 2" below and each tie positioned between the ties in the row above. Remember that ties need to be closer together than quilting lines because ties are holding the layers together in just one spot rather than in continuous lines.