I've done just that to audition quilt designs.
It's a great way to give a design a try for sure!
Good suggestion, GemRM to use the green painters tape at the edge,
to minimize the risk of drawing on one's quilt.
As a Caution .......when using the dry erase markers and wiping them off from the plastic.
....... there is a certain amount of "dust" left when you wipe off the design from the plastic, and it can sit on top, or that you can wipe off onto your quilt, if you take broad strokes. Plus, when you move the plastic, the dust can fall on top of your quilt, if you do not take care. You definitely do not want that embedding itself onto your quilt.
So just keep that in mind, and you won't have a problem.