Little Lulu

I am wanting to do a reversible quilt for my nephews. The two themes their parents want do not match or complement in colors at all. I can make it work by doing a reversible quilt: one side with fabrics relating to professional teams in their city and the other side with their favorite college theme fabrics.

Can I do one using the same quilt pattern on both sides? Is there any particular instructions in doing a reversible quilt in this manner? Thank you for the help.